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Finally, excessive lipid oxidation products (including proteins and DNA) may directly cause cytotoxicity

Autosomal means that the defect is not on the chromosomes that determine sex, and dominant means that you only need to inherit one changed gene to have the disease

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Truncated soluble His 6x tagged human FcRn lacking the transmembrane domain (hFcRn-His) was produced in a Baculovirus expression system and purified using a HisTrap HP column (Cytiva Life Sciences) 68,69